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Key Differences: Mechanism, Duration, and Side Effects Phentermine operates as a central nervous system stimulant that suppresses appetite through norepinephrine release, while GLP-1 agonists work through peptide hormone pathways that regulate multiple body systems simultaneously

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Drug interactions Individuals on long-term anticonvulsant (anti-seizure) therapy reportedly have reduced blood biotin concentrations, as well as an increased urinary excretion of organic acids (e.g., 3-hydroxyisovaleric acid) that indicate decreased carboxylase activity (see Markers of biotin status) (5)