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Wegovy comes as a single-dose autoinjector with a pre-attached needle

The big takeaway: retatrutide has similar GI side effects to semaglutide and tirzepatide, but with two unique additions -- dysesthesia (the skin sensitivity thing) and a slightly higher heart rate increase

Use is limited to qualified research settings

Patients treated with GLP-1RA will need to self-inject agents or have them administered subcutaneously anywhere from twice daily to once weekly depending on formulation

However, if one needs reductions in both fasting and postprandial glucose levels a longer acting agent such as repaglinide is a better choice