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Genetic variants such as GLP1R rs6923761 and GIPR rs1800437 may predict stronger or weaker receptor signaling, affecting weight-loss magnitude and gastrointestinal symptom intensity
Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial

Short-term cost savings from stopping are often offset by weight regain, which increases healthcare costs and may require medication restart