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MALE/LEA (RCTs): In 2 RCTs (n=3,592), MALE or lower-extremity amputation (LEA) did not differ vs placebo (event-driven limb endpoints remain underpowered in most CVOT-era trials)

While still in trial, side effects reported have been similar to existing GLP-1 medications, typically mild gastrointestinal issues

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The defense also suggests that they will aggressively defend Wegovy lawsuits that allege gastroparesis without objective testing confirming the diagnosis

The pattern that emerges from the STEP clinical trials is remarkably consistent across thousands of participants