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40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways

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First and foremost, this case series represents simple observation in a very small number of patients without a control group for comparison

The capacity to develop oxidative stress, arrhythmias, and HF are all associated with, and at least partly driven by, intracellular cardiomyocyte Na + and Ca 2+ concentrations [115,116,117]