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Further long-term, randomized controlled trials across diverse populations are necessary to definitively establish Berberines clinical effectiveness, optimal dosage, and long-term safety profile in managing metabolic health and obesity

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Last reviewed: July 11, 2026 Last updated: July 11, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

EXamination of cArdiovascular outcoMes with alogliptIN versus standard of carE in patients with type 2 diabetes mellitus and acute coronary syndrome (EXAMINE): a cardiovascular safety study of the dipeptidyl peptidase 4 inhibitor alogliptin in patients with type 2 diabetes with acute coronary syndrome

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