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Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking

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doi: 10.1016/S0140-6736(21)00213-0 [DOI] [PubMed] [Google Scholar] 234

Variability in enrollment might reflect local recruitment challenges or specific inclusion criteria, such as obesity or infertility in PCOS patients (Table 2)

Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population