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Fabry disease is present in all races and is an X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene that result in reduced alpha-galactosidase enzyme activity, leading to accumulation of lysosomal globotriaosylceramide (Gb3) globotriaosylsphingosine (lyso-Gb3) in affected tissues, including the heart, kidneys, vasculature, and peripheral nervous system

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Es importante destacar que la tirzepatida no est indicada para el tratamiento de la diabetes tipo 1 ni para la cetoacidosis diabtica, y no se requieren ajustes de dosis en pacientes con insuficiencia renal o heptica

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