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Description
A meta-analysis of randomized controlled trials (RCTs) including patients with HF found no improvement in hospitalization rates or echocardiographic parameters such as LVEF or LV end-systolic or diastolic volume

What matters now is how systems, insurers, and practices adapt, not just whether the drugs work

Lu J et al

Information sources We searched PubMed, Embase and Cochrane databases on 27 October 2021 for English-language studies

Moreover, one patient in the placebo group developed pancreatic cancer shortly after the end of the trial monitoring period