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2023;46(Supplement 1):S140S157

Indeed, the common hepatic branch, as well as celiac and gastric branches, have all been implicated in contributing to the glucoregulatory effects of gut GLP-1 62,125,126 , although selective knockdown of GLP-1R in nodose ganglia does not impair oral glucose tolerance or glucose-stimulated insulin secretion, similar to genetic knockout of GLP-1R in vagal neurons 127,128

These adverse effects are probably caused by the drugs themselves rather than by extraneous factors, as indicated by the results consistency across several studies and low degree of heterogeneity

J Biol Chem 1992;267:74025.PubMed 8

However, clinical studies have shown promising results: Average Weight Loss: Clinical trials indicate that people using GLP-1 for weight loss typically lose around 15-20% of their body weight over a period of 68 weeks (approximately 1 year and 3 months), when combined with a reduced-calorie diet and increased physical activity