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That figure reflects any measurable reduction rather than a defined clinical outcome so it should be read in that context

Safety profiles for early anti-obesity medication use remain favorable when properly monitored, with most adverse events being mild to moderate and no serious complications reported in clinical trials

Microbiome 9 , 34 (2021)

Retatrutide is not approved for medical use, and any compound supplied under this name is for laboratory research only, not for human consumption

Whether this should be regarded as specific metabolic treatment, targeting only the metabolic alterations of the syndrome, is debatable, since the improvement in metabolic conditions, e.g., insulin resistance, would tenably have a positive impact also in gonadal function in women with PCOS