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Description
DPP-4 inhibitors have a half-life of 12.4 to 24 hours and are dosed once daily
Liver fat reduction by dose At the 1mg dose, liver fat decreased by 42.9% at 24 weeks
The disadvantage is precision at lower doses
Of note is that the observed median time to onset of the psychiatric AEs in our analysis of the FAERS data aligned with common gastrointestinal AEs such as nausea and vomiting, which were the most frequently reported within the first 30 days of GLP-1 RA treatment (29)
Gastrointestinal bleeding, ulcer disease, and hemorrhagic stroke remain clinically significant risks, particularly in older adults
