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In Pennsylvania, a $3.5 billion facility in Fogelsville, announced in January 2026 and beginning construction in 2026, will manufacture tirzepatide and next-generation peptides including retatrutide, with completion expected in 2031

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Semaglutide Side Effects and Safety Semaglutide is generally well tolerated, with the most common side effects being nausea, mild vomiting, diarrhea, or constipation particularly during the early dose escalation phase
