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Tirzepatide in addition to being a GLP-1 receptor agonist like Semaglutide, it also is a GIP receptor agonist and increases energy expenditure resulting in weight loss
Diabetes Care 42(9):e141e142

After standardizing for various factors, GLP1 RA compared with metformin was associated with reduced 1year risk of addon glucoselowering treatment in patients with prediabetes (1year risk ratio [RR]: 0.27, 95% confidence interval [CI]: 0.100.44) and diabetes (RR: 0.67, 95% CI: 0.370.98)

They are actively involved in research to develop new formulations and enhance therapeutic efficacy