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For obese patients I think the initial focus should be on the patients with severe and morbid obesity first
A trial called STOP Knee OA is currently investigating this question more directly

Beyond Weight Loss As a leader in the field, Caitlin even provides professional education to other providers

Like any therapy, GLP-1 treatment carries risks that depend on your history and health, which is exactly why we screen with labs, start low, and recheck rather than handing over an injection and walking away

Jo D, Choi SY, Ahn SY, Song J (2025) IGF1 enhances memory function in obese mice and stabilizes the neural structure under insulin resistance via AKT-GSK3-BDNF signaling