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Although this first reported analgesic effect of a GLP-1 analogue was likely mediated by its local anti-inflammatory action, GLP-1R is also expressed in dorsal root ganglion (DRG) neurons [86] and therefore could directly act on nociceptive pain in OA DRG neurons endings are present in synovium [87]
Similarly, among those not using CPAP, GLP-1 RAs showed a trend toward significance (MD: 1.49 mmHg
However, the long half-life smooths this out over time, reducing steady-state variability to about 33%
Mounjaro
