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Retatrutide, also known as LY-3437943 or triple G is an investigational multi-agonist peptide studied for its activity at GLP-1, GIP and glucagon receptors

In a comprehensive US administrative database from 2005 to 2008, GLP-1-based treatments, particularly sitagliptin and exenatide, were associated with a significantly increased risk of acute pancreatitis-related hospitalization in adults with T2DM [59], thereby reinforcing prior mechanistic experimental studies and spontaneous reports to the FDA suggesting a potential causal relationship