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Research suggests that muscle lossas indicated by decreases in fat-free mass (which includes muscle as well as bones, water, and organs)with the medications ranges from 25% to 39% of total weight loss throughout 36 to 72 weeks, according to a 2024 study
The simplest difference is this: weekly GLP-1 injections are typically chosen for patients who want a more traditional, structured, once-weekly treatment routine , while daily GLP-1 ODTs may appeal to patients who prefer to avoid injections and want a needle-free option that fits into a daily habit

Personalized GLP-1 Selection: Finding Your Best Option Your response to any weight loss medicationwhether oral, injectable, or combineddepends partly on your genetic predisposition to GLP-1 and GIP receptor signaling
[DOI] [PubMed] [Google Scholar] 18.Wing RR, Shoemaker M, Marcus MDM, McDermott M, Gooding W
