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Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice

The authors point out that other studies have shown heightened levels of circulating GLP-1 in critically ill patients7, who would presumably have some degree of impaired intestinal barrier function

doi:10.36849/JDD.6550 Samantha Ouellette BA, Giulia Frias BA, Radhika Shah MD PharmD, Mahin Alamgir MD, Cindy Wassef MD Department of Dermatology, Rutgers Robert Wood Johnson Medical School, Somerset, NJ Abstract Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of antidiabetic agents that work by inducing insulin secretion and inhibiting release of glucagon in a glucose-dependent manner

There were no statistically significant differences in post-hoc testing

Potential signals have already emerged in the case of GLP-1 mimetic therapy, one is pancreatitis (1214) and another, which is currently confined to rodents studies, is thyroid cancer (11)