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First, it provides a comprehensive investigation of the associations between GLP-1RAs and 12 common psychiatric and neurodevelopmental conditions, utilizing large-scale GWAS summary statistics

Some people need careful meal timing, smaller portions, and avoiding lying down after meals for longer

5.2 Oxyntomodulin as an endogenous polypharmacologic signal As discussed in Section 4.4, it also plays a central role in appetite regulation in the context of metabolic peptides

Second, while multiple brain regions have been explored in isolation, few studies have performed integrative circuit-level analyses across interconnected reward nodes, which may underestimate system-level interactions