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In a 2015 meta-analysis, the mean reduction of weight for GLP-1 RAs was -1.01 kg to -1.62 kg compared to placebo

Nakata, Y., Ohkawara, K., Lee, D

The difference between prebiotics and probiotics is that prebiotics feed beneficial bacteria already living in the gut, while probiotics introduce live microbes that may support microbial balance

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The difference in their mechanisms of action makes a potential interaction unlikely