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Incretin-based medications and investigational drugs like Retatrutide are commonly associated with gastrointestinal side effects such as nausea, vomiting, diarrhea, constipation, and reduced appetite

Fatigue persisting beyond 8-12 weeks despite stable dosing, fatigue accompanied by dizziness or shortness of breath, or fatigue that interferes with daily function warrants provider evaluation

Limit fried foods, heavy cream sauces, fatty cuts of meat, and full-fat dairy products, especially during the initial titration phase when side effects are most common

GLP-1 is a hormone naturally produced in the gut after eating

Compounded oral and sublingual formats have no published trial data, so a low oral price buys an unproven format