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Of the 53 100 eligible for inclusion, 2003 were identified as GLP1 RA initiators, and 51 097 were identified as metformin users

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Caution Despite its strengths including a large sample size and propensity matching this is an observational study that is subject to confounders and bias

In a study conducted in obese male patients all exenatide responders, defined as those who consumed lower food calories by exenatide administration compared to placebo, exhibited significantly higher hypothalamic connectivity measured by food cue-paired fMRI compared with placebo injection [41]