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Growing Use in Obesity Treatment: As GLP-1 receptor agonists gain recognition as an effective treatment for obesity, the parenteral route remains the preferred method due to its efficiency in delivering the necessary dosage for weight management
GLP-1 fatigue is primarily a higher-dose phenomenon

American Diabetes Association Professional Practice Committee

In a recent randomized trial, one year of combined GLP-1 therapy with exercise training preserved bone mineral density, while GLP-1 therapy alone decreased bone mineral density [162]
