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As of 2026, these are the milestones that ended broad GLP-1 compounding: Tirzepatide Shortage declared resolved on October 2, 2024 , and reaffirmed after a legal challenge on December 19, 2024

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Practical Considerations for Clinicians When discussing the potential blood pressure effects of GLP-1 medications with patients, careful framing is essential

Avoid alcohol for 1 to 2 weeks after each increase until side effects settle