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Additionally, tirzepatide may affect the absorption of oral medications due to delayed gastric emptying, which is relevant for drugs with narrow therapeutic windows

70 Patients who proactively follow dietary changes may require greater dose reductions of sulphonylureas or insulin to avoid hypoglycaemia

So the question is: Is there going to be increased pressure on the starting doses of tirzepatide and semaglutide? The restrictions on compounded GLP-1 products come as concerns about existing shortages are bubbling

In clinical weight loss studies, tirzepatide has generally produced greater average weight loss than semaglutide at studied therapeutic doses