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Most current guidelines recommend against initiating glyburide during pregnancy

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Specifically, researchers discovered that the L cells found in the ileum, the final and longest part of the small intestine, release two important gut peptides: GLP-1 and peptide tyrosine tyrosine (PYY), both of which contribute to satiety and the regulation of appetite and food intake

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Kidney function markers such as creatinine and eGFR remain stable in most patients, though your doctor will monitor these at baseline and periodically during therapy