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Strategies to increase half-life To design GLP-RAs with an increased circulation time, a broad array of half-life extension strategies has been utilized including sequential modification (Byetta and Adlyxin), attachment of a fatty-acid (Victoza and Ozempic), development of a polymer-based sustained release formulation (Bydureon), fusion with human serum albumin (Tanzeum), and fusion with the fragment crystallizable (Fc) region of a monoclonal antibody (Trulicity) (Figure 1)

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Reduced blood sugar levels Improved insulin sensitivity Decreased risk factors for cardiovascular disease Reduced risk of obesity-related comorbidities Frequently Asked Questions Get answers to common questions about the program Have Questions About Semaglutide

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So I think seeing the progression of that and looking at outcome studies will be key before we make a decision of whether or not we want to include that in our care. Road to Reimbursement Because GLP-1s are a new drug within health care in general and there are not yet any clinical standards for its use across substance use disorder care, serious mental illnesses or eating disorders, the road to eventual reimbursement for including it in care is one all practitioners told BHB they will be closely monitoring