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Published Phase 2 trial data (NEJM, 2023) demonstrated substantial reductions in body weight in some participants exceeding 20% over approximately 48 weeks making retatrutide one of the most potent agents currently in development for obesity and metabolic disease

Approval of tirzepatide (brand name Mounjaro/Zepbound), an even more efficacious medication, soon followed in 2023

January 26, 2023

Nevertheless, this information is provided "as is" without any guarantee of accuracy, timeliness, completeness, or usefulness for any particular purpose

Increasingly, AITD coexists with metabolic disorders such as obesity, insulin resistance, and metabolic dysfunction-associated steatotic liver disease (MASLD), suggesting an interplay between immune dysregulation and metabolic health