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GI Tolerability Differences Some patients experience persistent nausea on semaglutide but find tirzepatide easier to tolerate at equivalent dose stages, or vice versa
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For the primary efficacy outcome, HbA1c change, if a heterogeneous result was robust, a meta-regression analysis was carried out to further investigate which prespecified clinical characteristics may be potential sources of the intertrial heterogeneity

Those who do discontinue must maintain healthy lifestyle behaviors to sustain their weight loss and decreased risk for chronic disease