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Support for this hypothesis comes from the finding that, in ovariectomized rats, estradiol replacement enhances peripheral GLP-1 induced suppression on food intake (199, 200)

This dose sits in a range that many practitioners consider the sweet spot, strong enough for significant results but lower than the doses most associated with severe GI effects

Endocrinology 151 , 46784687 (2010)

Heart rate increased in a dose-dependent pattern up to 24 weeks and then declined later in the trial

Type 2 diabetes with cardiovascular or kidney risk Obesity or overweight with comorbidities, where meaningful weight loss would change your risk Obesity-related OSA or knee osteoarthritis where GLP-1s can treat upstream weight and symptoms Have we done the foundations