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Description
Techniques like ion-pairing reversed-phase liquid chromatography (IP-RPLC) are widely used to monitor peptide critical quality attributes (CQAs), with hyphenated LC-MS approaches playing a key role in enhancing sensitivity and selectivity, enabling quantification of low-level impurities
3.3.2 Harms: Risk of Ketoacidosis: The major concern is the development of diabetic ketoacidosis (DKA), including euglycemic DKA
Besides, patients with diabetes may already have a predisposition to diabetic neuropathy, potentially masking or confounding drug-related NAEs
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