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These gastrointestinal effects are typically mild with the starting dose and tend to diminish within the first few weeks

Metformin continuation or discontinuation: Some providers continue metformin for its modest additional benefit and low cost

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Espay tells NBC News that it makes sense that GLP-1s seem to help protect the brain because Alzheimers is a syndrome of many diseases caused by different biological, toxic or infectious exposures. In the treatment group, 79 people completed a year of treatment, as did 87 people in the placebo group

Behavioural treatment strategies improve adherence to lifestyle intervention programmes in adults with obesity: a systematic review and meta-analysis