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Abbreviations ACE2 Angiotensin-converting enzyme 2 Ang-1-7 Angiotensin 1-7 BALF Bronchoalveolar lavage fluid CAD Cinnamaldehyde CDC US Centers for Disease Control and Prevention CO Carbon monoxide COPD Chronic obstructive pulmonary disease COVID-19 Coronavirus disease 2019 CS Cigarette smoke ENDS Electronic nicotine dispensing systems EVALI e-cigarette or vaping product use-associated lung injury FDA Food and Drug Administration GC-FID Gas chromatography with a flame ionisation detector GCMS Gas chromatography-mass spectrometry GM-CSF Granulocytemacrophage colony-stimulating factor HPLC High performance liquid chromatography HUVEC Human umbilical vein endothelial cells IL Interleukin IFN Interferon KO Knockout LCMS Liquid chromatography-mass spectrometry MCP-1/CCL2 Monocyte chemoattractant protein-1 MMP-9 Matrix metallopeptidase 9 nAChR7 7 Nicotinic acetylcholine receptor NC Nickelchromium alloy NO Nitric oxide PG Propylene glycol RANTES/CCL5 Regulated on activation, normal T cell expressed and secreted ROS Reactive oxygen species SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 SS Stainlesssteel atomizer THC Tetrahydrocannabinol TNF Tumour necrosis factor- WT Wild type Authors' contributions All authors discussed and agreed to the scope of the manuscript and contributed to the development of the manuscript at all stages

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Potential explanations are: 1) the message was not persuasive enough, especially the section where NRTs effectiveness in helping smokers quit was described

Anti-Tumor Activity of High-Dose EGFR Tyrosine Kinase Inhibitor and Sequential Docetaxel in Wild Type EGFR Non-Small Cell Lung Cancer Cell Nude Mouse Xenografts