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[B]efore marketing tobacco products for reduced risk, companies must demonstrate with scientific evidence that their specific product does in fact pose less risk or is less harmful, the FDA said in a statement

Smoking and Vascular Smooth Muscle Cells Under normal physiological conditions, the relaxation and contraction of smooth muscle cells in the arterial wall is necessary to maintain relatively stable blood flow and blood pressure

Atherosclerosis-prone apolipoprotein E-deficient ( Apoe-/-) mice are used as an animal model of atherosclerosis and more generally for understanding the pathophysiology of cardiovascular diseases [60]

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