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The agency ordered Juul to stop immediately

The central nicotinic cholinergic receptors, namely the low affinity 7 and the high affinity 42 nicotinic receptors located in the ventral tegmental area (VTA), are stimulated by nicotine resulting in a rapid release of dopamine in the nucleus accumbens, mediating the rewarding and reinforcing effects of nicotine (25) (Figure 1)

Jung J, Moon SM, Jang HC, Kang CI, Jun JB, Cho YK, et al

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BJOG 127 , 171180 (2020)
