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Studies have shown that administration of nicotine in rats causes an increase in Basal layer collagen fibers, destruction of Sertoli cell intercellular connections, chromosomal abnormalities, degenerative germ cells, excessive accumulation of fat droplets in the sperm cytoplasm, and morphological abnormalities in the sperm [37]

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Population pharmacokinetics of clozapine and its primary metabolite norclozapine in Chinese patients with schizophrenia