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Excessive levels of glucose and free fatty acids induce stress in insulin-sensitive tissues resulting in the release of several cytokines and chemokines including CRP, fibrinogen, plasminogen activator inhibitor (PAI), IL-1, TNF-, CC-chemokine ligand 2 (CCL2), CCL3, CXC-chemokine ligand 8 [55, 56]

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At the same time, caravans from Morocco brought tobacco to the area around Timbuktu, and the Portuguese brought the commodity (and the plant) to southern Africa

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