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Despite the widely held belief that marijuana is safe to use, research has shown increased health risks for those who smoke the substance

Particularly, PAHs formed during incomplete tobacco combustion influence the hepatic cytochrome P450 (CYP450) enzyme system, especially by induction of isoenzymes CYP1A1, 1A2, 1B1, and 2E1, leading to accelerated drug clearance, potentially lowering blood concentrations
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Sussan, T
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"Excise stamps Information for consumers"
