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Nature 332(6163):411415 Zhang JY et al (2006) Lipid-soluble smoke particles damage endothelial cells and reduce endothelium-dependent dilatation in rat and man

Chemical Irritation E-cigarette liquids contain thousands of different substances, many of which haven't been tested for safety in humans

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Conclusion Smoking is a chronic relapsing disease and thus quitting is one of the single most important interventions to improve health outcomes, regardless of age or length of smoking history