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The activation of NRF2 and the upregulation of cytochrome p450 in response to cigarette smoke extract, but not to electronic cigarette aerosol extract in human coronary endothelial cells supports this concept [96]

10.1038/s41366-018-0050-0 152
This step is critical - the longer you go before treatment, the worse the condition may become

Blandford explained

Animal studies have shown that this is particularly true while the brain is still developing
