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We have added to the text of the Stage 5 section "Our manuscript will include a discussion section that will highlight important and or surprising results from this review, discuss additional research questions identified, discuss the limitations of this review, and comment on the quality of the evidence identified." We have also added "and discussion" to the first sentence of the Stage 5 section of our manuscript to clarify that the PRISMA- ScR checklist will be used to inform the writing of our discussion section in addition to our results section

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As was documented, younger male patients with early-onset PCa have risen over the past 3 decades, and had the highest mortality among all age groups, since they were inclined to have a higher risk or metastatic form [24,25,26]