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1987), 5-hydroxycotinine (also called allohydroxycotinine) (Neurath 1994), which exists in tautomeric equilibrium with the open chain derivative 4-oxo-4-(3-pyridyl)- N -methylbutanamide, cotinine N -oxide, cotinine methonium ion, cotinine glucuronide, and norcotinine (also called demethylcotinine)

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Hypoxia induces p53 which mediates cellular apoptosis [18], both of which are upregulated in the Hallmark gene set analysis (i.e

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