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it compromises the responses of the bronchial epithelium by modifying the expression and activation of innate immunity receptors and determines the destruction of desmosomes and tight junctions with increased permeability to allergens, pollutants, and infectious agents and the release of inflammatory mediators (IL-8, IL-1, sICAM-1) 15

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Highest receptivity was for e-cigarettes followed by cigarettes, smokeless tobacco, and cigars