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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

In this pilot study, out of the 30 subjects in both the groups, there were about 8 subjects belonging to low dependence group, 3 of low-to-moderate dependence, about 16 subjects in both the groups with high dependence, and about 3 patients with very high dependence in both the groups

Although the COD of leachates from the recycling of different cigarette filter samples had a significant difference, but an insignificant difference was observed in the turbidity

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Therefore, careful assessment of safety and efficacy profiles of co-administered medications in TB patients who also smoke are warranted to avoid ADRs and achieve therapeutic goals