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Psychological dependence is characterized by repeated use of a drug, the fear of stopping, and negative consequences and physical dependence involves increasing tolerance, cravings, and withdrawal symptoms

Smoking: Two related studies, one in humans and the other in rats, found that the cardiovascular effects of cigarettes and e-cigarettes are strikingly similar, and these harmful effects on blood vessel function are likely caused by airway irritation due to inhalation of a foreign substance, rather than a specific component of the cigarette smoke or e-cigarette vapor (aerosol).

Socioeconomic factors that limit access to cessation resources or education