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Effects of Cigarette Smoke Exposure on Innate Immunity The innate defense mechanisms of the airways and lungs encompass structural components, cough reflex, mucociliary clearance, epithelial barrier, humoral factors (surfactant proteins, complement proteins, antimicrobial peptides), and cells that elicit immune responses (epithelial cells, macrophages, monocytes, dendritic cells, neutrophils, natural killer cells, and mast cells)

However, a closer examination reveals that cigars pose their own set of risks

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Slater, SJ, Chaloupka FJ, Wakefield M, Johnston LD, O'Malley PM

In summary, the general consensus in medical research is that nicotine does raise blood pressure