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People have consumed the leaves of the tobacco plant in various forms for thousands of years

Traditionally, a user prepares this at the time of use

When researchers looked at specific causes of death among study participants, a particularly strong association was observed for lung cancer mortality

2001 Urban and Rural Health Chartbook

Riccardo Polosa, Center of Excellence for the Acceleration of HArm Reduction (CoEHAR), University of Catania, Italy, Centre for the Prevention and Treatment of Tobacco Addiction (CPCT), Catania, Italy, Department of Clinical & Experimental Medicine, University of Catania, Catania, Italy