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66 An analysis from a Cochrane review including 11 studies showed that varenicline prevents relapse in those who abstain from smoking, based on moderate-certainty evidence (risk ratio [RR], 1.23

5-7, 10 Because of the way this medication mimics the presence of nicotine and attaches to the nicotinic acetylcholine receptors in the brain, it is not designed to be used in combination with nicotine replacement therapy unless directed otherwise by a health care provider

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doi: 10.1210/endrev/bnaa002