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The hepatotoxicity of PZA is dose-dependent, especially at doses above 40 mg/kg, and correlates with its hepatic metabolism, suggesting a direct toxic effect rather than a hypersensitive or immune-mediated mechanism

In the post-ban period, the proportion of beginners remained approximately constant at 22% (n=88), but the percentage of experienced users increased to 41.5% (n=166), reflecting an 18% relative increase

Everyone did it, including me

Truglio is now in jail awaiting the next phase of his trial, according to Italian prosecutors, while other members of the smuggling ring were arrested in Italy or Moldova for either cigarette smuggling or other crimes, and one was acquitted